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Publication year
2020Source
Cardiovascular Research, 116, 4, (2020), pp. 829-840ISSN
Publication type
Article / Letter to editor

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Organization
Cardiology
Journal title
Cardiovascular Research
Volume
vol. 116
Issue
iss. 4
Page start
p. 829
Page end
p. 840
Subject
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health SciencesAbstract
Ischaemic heart disease is a leading cause of morbidity and mortality in both women and men. Compared with men, symptomatic women who are suspected of having myocardial ischaemia are more likely to have no obstructive coronary artery disease (CAD) on coronary angiography. Coronary vasomotor disorders and coronary microvascular dysfunction (CMD) have been increasingly recognized as important contributors to angina and adverse outcomes in patients with no obstructive CAD. CMD from functional and structural abnormalities in the microvasculature is associated with adverse cardiac events and mortality in both sexes. Women may be particularly susceptible to vasomotor disorders and CMD due to unique factors such as inflammation, mental stress, autonomic, and neuroendocrine dysfunction, which predispose to endothelial dysfunction and CMD. CMD can be detected with coronary reactivity testing and non-invasive imaging modalities; however, it remains underdiagnosed. This review focuses on sex differences in presentation, pathophysiologic risk factors, diagnostic testing, and prognosis of CMD.
This item appears in the following Collection(s)
- Academic publications [227683]
- Electronic publications [107287]
- Faculty of Medical Sciences [86198]
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