Identifying effector molecules, cells, and cytokines of innate immunity in OA
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SourceOsteoarthritis and Cartilage, 28, 5, (2020), pp. 532-543
Article / Letter to editor
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Osteoarthritis and Cartilage
SubjectRadboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life Sciences
Inflammatory changes are observed in affected joints of osteoarthritis (OA) patients and are thought to be involved in the pathology that develops along OA progression. This narrative review provides an overview of the various cell types that are present in the joint during OA and which alarmins, cytokines, chemokines, growth factors, and other mediators they produce. Moreover, the involvement of more systemic processes like inflammaging and its associated cellular senescence in the context of OA are discussed.
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