High-resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels.
Publication year
2020Source
Protein Science, 29, 7, (2020), pp. 1569-1580ISSN
Annotation
01 juli 2020
Publication type
Article / Letter to editor

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Organization
Physiology
Journal title
Protein Science
Volume
vol. 29
Issue
iss. 7
Page start
p. 1569
Page end
p. 1580
Subject
Radboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Transient receptor potential vanilloid (TRPV) channels are part of the superfamily of TRP ion channels and play important roles in widespread physiological processes including both neuronal and non-neuronal pathways. Various diseases such as skeletal abnormalities, chronic pain, and cancer are associated with dysfunction of a TRPV channel. In order to obtain full understanding of disease pathogenesis and create opportunities for therapeutic intervention, it is essential to unravel how these channels function at a molecular level. In the past decade, incredible progress has been made in biochemical sample preparation of large membrane proteins and structural biology techniques, including cryo-electron microscopy. This has resulted in high resolution structures of all TRPV channels, which has provided novel insights into the molecular mechanisms of channel gating and regulation that will be summarized in this review.
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- Academic publications [227864]
- Electronic publications [107344]
- Faculty of Medical Sciences [86218]
- Open Access publications [76463]
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