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Title: Adipokines: A gear shift in puberty
Author(s): Nieuwenhuis, D.; Pujol-Gualdo, N.; Arnoldussen, I.A.C. ; Kiliaan, A.J.
Publication year: 2020
Source: Obesity Reviews, vol. 21, iss. 6, (2020), article e13005
ISSN: 1467-7881
DOI: https://doi.org/10.1111/obr.13005
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/220685   https://hdl.handle.net/2066/220685

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Subject: Radboudumc 1: Alzheimer`s disease DCMN: Donders Center for Medical Neuroscience
Organization: Medical Imaging
Journal title:
Obesity Reviews
Volume: vol. 21
Issue: iss. 6
Article number: e13005
Abstract:
In this review, we discuss the role of adipokines in the onset of puberty in children with obesity during adrenarche and gonadarche and provide a clear and detailed overview of the biological processes of two major players, leptin and adiponectin. Adipokines, especially leptin and adiponectin, seem to induce an early onset of puberty in girls and boys with obesity by affecting the hypothalamic-pituitary-gonadal (HPG) axis. Moreover, adipokines and their receptors are expressed in the gonads, suggesting a role in sexual maturation and reproduction. All in all, adipokines may be a clue in understanding mechanisms underlying the onset of puberty in childhood obesity and puberty onset variability.

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