Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH(4)) deficiencies
Publication year
2020Author(s)
Source
Orphanet Journal of Rare Diseases, 15, 1, (2020), article 126ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Laboratory Medicine
Journal title
Orphanet Journal of Rare Diseases
Volume
vol. 15
Issue
iss. 1
Subject
Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical NeuroscienceAbstract
BACKGROUND: Tetrahydrobiopterin (BH(4)) deficiencies comprise a group of six rare neurometabolic disorders characterized by insufficient synthesis of the monoamine neurotransmitters dopamine and serotonin due to a disturbance of BH(4) biosynthesis or recycling. Hyperphenylalaninemia (HPA) is the first diagnostic hallmark for most BH(4) deficiencies, apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency and sepiapterin reductase deficiency. Early supplementation of neurotransmitter precursors and where appropriate, treatment of HPA results in significant improvement of motor and cognitive function. Management approaches differ across the world and therefore these guidelines have been developed aiming to harmonize and optimize patient care. Representatives of the International Working Group on Neurotransmitter related Disorders (iNTD) developed the guidelines according to the SIGN (Scottish Intercollegiate Guidelines Network) methodology by evaluating all available evidence for the diagnosis and treatment of BH(4) deficiencies. CONCLUSION: Although the total body of evidence in the literature was mainly rated as low or very low, these consensus guidelines will help to harmonize clinical practice and to standardize and improve care for BH(4) deficient patients.
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- Academic publications [227425]
- Electronic publications [107155]
- Faculty of Medical Sciences [86157]
- Open Access publications [76288]
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