Does entry to center-based childcare affect gut microbial colonization in young infants?
Number of pages
SourceScientific Reports, 10, (2020), article 10235
Article / Letter to editor
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SW OZ BSI ON
PI Group Memory and Emotion
SubjectRadboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Social Development
Entry to center-based childcare (CC) at three months of life can be an important challenge for infants as it includes major stressors such as long maternal separations and frequently changing caregivers. Stress and the new environment may in turn alter the composition of the gut microbiota with possible implications for future health outcomes. As part of an ongoing longitudinal study, we investigated whether CC, as compared to being cared for by the parents at home, alters the composition of the gut microbiota, while accounting for known covariates of the infant gut microbiota. Stool samples of infants who entered CC (n = 49) and control infants (n = 49) were obtained before and four weeks after CC entrance. Using Redundancy analysis, Random Forests and Bayesian linear models we found that infant gut microbiota was not affected in a uniform way by entry to CC. In line with the literature, breastfeeding, birth mode, age, and the presence of siblings were shown to significantly impact the microbial composition.
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