Development of a new patient-reported outcome measure to assess activities and participation in people with systemic sclerosis: The Cochin 17-item Scleroderma Functional Scale
Number of pages
SourceBritish Journal of Dermatology, 183, 4, (2020), pp. 710-718
Article / Letter to editor
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SW OZ BSI KLP
British Journal of Dermatology
SubjectExperimental Psychopathology and Treatment
Objectives: To develop a new patient-reported outcome measure assessing activities and participation in people with systemic sclerosis (SSc). Methods: A provisional International Classification of Functioning, Disability and Health (ICF)-based 65-item questionnaire previously developed from interviews of people with SSc was sent by email to all patients followed in the internal medicine department of Cochin hospital (n=184) and enrolled in the Scleroderma Patient-centered Intervention Network Cohort. Items were reduced according to their metric properties. Dimensional structure of the questionnaire was assessed by principal component analysis, convergent and divergent validities by the Spearman correlation coefficient (ρ), internal consistency by the Cronbach alpha coefficient, and reliability by a test-retest method using intraclass correlation coefficient (ICC) and Bland and Altman analysis. Results: Overall, 113/184 (61.4%) patients completed the provisional questionnaire. The item-reduction process resulted in a 17-item questionnaire, the Cochin 17-item Scleroderma Functional scale (CSF-17). Principal component analysis extracted 2 dimensions: 10 items related to mobility (CSF-17 section A) and 7 items related to general tasks (CSF-17 section B). We observed convergent validity of the CSF-17 total score with global activity limitation, pain, depression and aesthetic burden, and divergent validity with anxiety. The Cronbach α coefficient was 0.94 for section A and 0.95 for section B. ICC (n=25 patients) was 0.92 for CSF-17 total score. Bland and Altman analysis did not reveal a systematic trend for the test-retest. Conclusions: The CSF-17 is a new patient-reported outcome assessing activities and participation specifically in people with SSc. Its content and construct validities are very good.
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