[(99m)Tc]-labelled interleukin-8 as a diagnostic tool compared to [(18)F]FDG and CT in an experimental porcine osteomyelitis model
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Publication year
2020Source
American Journal of Nuclear Medicine and Molecular Imaging, 10, 1, (2020), pp. 32-46ISSN
Publication type
Article / Letter to editor
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Organization
Medical Imaging
Journal title
American Journal of Nuclear Medicine and Molecular Imaging
Volume
vol. 10
Issue
iss. 1
Page start
p. 32
Page end
p. 46
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Radboudumc 14: Tumours of the digestive tract RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 19: Nanomedicine RIMLS: Radboud Institute for Molecular Life Sciences; Medical Imaging - Radboud University Medical CenterAbstract
Osteomyelitis (OM) is an important cause of morbidity and sometimes mortality in children and adults. Long-term complications can be reduced when treatment is initiated in an early phase. The diagnostic gold standard is microbial examination of a biopsy and current non-invasive imaging methods are not always optimal. [(111)In]-leukocyte scintigraphy is recommended for peripheral OM, but is time-consuming and not recommended in children. [(18)F]FDG PET/CT is recommended for vertebral OM in adults, but has the disadvantage of false positive findings and a relatively high radiation exposure; the latter is a problem in children. [(99m)Tc]-based tracers are consequently preferred in children. We, therefore, aimed to find a [(99m)Tc]-marked tracer with high specificity and sensitivity for early detection of OM. Suppurating inflammatory lesions like OM caused by Staphylococcus aureus (S. aureus) will attract large numbers of neutrophils and macrophages. A preliminary study has shown that [(99m) Tc]-labelled IL8 may be a possible candidate for imaging of peripheral OM. We investigated [(99m)Tc]IL8 scintigraphy in a juvenile pig model of peripheral OM and compared it with [(18)F]FDG PET/CT. The pigs were experimentally inoculated with S. aureus to induce OM and scanned one week later. We also examined leukocyte count, serum CRP and IL8, as well as performed histopathological and microbiological investigations. [ (99m) Tc]IL8 was easily and relatively quickly prepared and was shown to be suitable for visualization of OM lesions in peripheral bones detecting 70% compared to a 100% sensitivity of [(18)F]FDG PET/CT. [ (99m) Tc]IL8 is a promising candidate for detection of OM in peripheral bones in children.
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