Principles of temporal association cortex organisation as revealed by connectivity gradients
Number of pages
SourceBrain Structure and Function, 225, 4, (2020), pp. 1245-1260
Article / Letter to editor
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SW OZ DCC SMN
PI Group Statistical Imaging Neuroscience
SW OZ DCC CO
Brain Structure and Function
Subject220 Statistical Imaging Neuroscience; Action, intention, and motor control; Radboudumc 12: Sensory disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience; Language in Interaction
To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffusion MRI tractography data to investigate the organisational principles of the human temporal association cortex. We identify three overlapping gradients of connectivity that are, for the most part, consistent across hemispheres. The first gradient reveals an inferior–superior organisation of predominantly longitudinal tracts and separates visual and auditory unimodal and multimodal cortices. The second gradient radiates outward from the posterior middle temporal cortex with the arcuate fascicle as a distinguishing feature; the third gradient is concentrated in the anterior temporal lobe and emanates towards its posterior end. We describe the functional relevance of each of these gradients through the meta-analysis of data from the neuroimaging literature. Together, these results unravel the overlapping dimensions of structural organization of the human temporal cortex and provide a framework underlying its functional multiplicity.
NWO (Grant code:info:eu-repo/grantAgreement/NWO/Gravitation/024.001.006)
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