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Publication year
2016Number of pages
8 p.
Source
Current Biology, 26, 4, (2016), pp. 450-457ISSN
Publication type
Article / Letter to editor

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Organization
PI Group Memory and Space
PI Group Neurobiology of Language
Neuroinformatics
Journal title
Current Biology
Volume
vol. 26
Issue
iss. 4
Languages used
English (eng)
Page start
p. 450
Page end
p. 457
Subject
110 000 Neurocognition of LanguageAbstract
Integration of separate memories forms the basis of inferential reasoning-an essential cognitive process that enables complex behavior. Considerable evidence suggests that both hippocampus and medial prefrontal cortex (mPFC) play a crucial role in memory integration. Although previous studies indicate that theta oscillations facilitate memory processes, the electrophysiological mechanisms underlying memory integration remain elusive. To bridge this gap, we recorded magnetoence-phalography data while participants performed an inference task and employed novel source reconstruction techniques to estimate oscillatory signals from the hippocampus. We found that hippocampal theta power during encoding predicts subsequent memory integration. Moreover, we observed increased theta coherence between hippocampus and mPFC. Our results suggest that integrated memory representations arise through hippocampal theta oscillations, possibly reflecting dynamic switching between encoding and retrieval states, and facilitating communication with mPFC. These findings have important implications for our understanding of memory-based decision making and knowledge acquisition.
This item appears in the following Collection(s)
- Academic publications [202652]
- Donders Centre for Cognitive Neuroimaging [3345]
- Electronic publications [100805]
- Faculty of Science [31824]
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