Establishing drug effects on electrocorticographic activity in a genetic absence epilepsy model: Advances and pitfalls
Source
Frontiers in Pharmacology, 11, (2020), article 395ISSN
Publication type
Article / Letter to editor

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Organization
SW OZ DCC SMN
SW OZ DCC BO
Journal title
Frontiers in Pharmacology
Volume
vol. 11
Languages used
English (eng)
Subject
Action, intention, and motor controlAbstract
The genetic rat models such as rats of the WAG/Rij strain and GAERS were developed as models for generalized genetic epilepsy and in particular for childhood absence epilepsy. These animal models were described in the eighties of the previous century and both models have, among others, face, construct and predictive validity. Both models were and are currently used as models to predict the action of antiepileptic medication and other experimental treatments, to elucidate neurobiological mechanisms of spike-wave discharges and epileptogenesis. Although the electroencephalagram (EEG)/electrocorticogram (ECoG) is imperative for establishing absence seizures and to quantify the for absence epilepsy typical spike-wave discharges, monitoring the animals behavior is equally necessary. Here an overview is given regarding the design of drug evaluation studies, which animals to use, classical and new EEG variables, the monitoring and quantification of the behavior of the rats, some pitfalls regarding the interpretation of the data, and some developments in EEG technology.
This item appears in the following Collection(s)
- Academic publications [203856]
- Electronic publications [102284]
- Faculty of Social Sciences [27309]
- Open Access publications [70941]
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