Medial prefrontal decoupling from the default mode network benefits memory
Number of pages
SourceNeuroImage, 210, (2020), article 116543
Article / Letter to editor
Display more detailsDisplay less details
PI Group Memory and Emotion
SW OZ BSI OLO
PI Group Affective Neuroscience
PI Group Statistical Imaging Neuroscience
Subject130 000 Cognitive Neurology & Memory; 220 Statistical Imaging Neuroscience; 230 Affective Neuroscience; All institutes and research themes of the Radboud University Medical Center; Learning and Plasticity; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
In the last few years the involvement of the medial prefrontal cortex (mPFC) in memory processing has received increased attention. It has been shown to be centrally involved when we use prior knowledge (schemas) to improve learning of related material. With the mPFC also being one of the core hubs of the default mode network (DMN) and the DMN's role in memory retrieval, we decided to investigate whether the mPFC in a schema paradigm acts independent of the DMN. We tested this with data from a cross-sectional developmental study with a schema paradigm. During retrieval of schema items, the mPFC decoupled from the DMN with the degree of decoupling predicting memory performance. This finding suggests that a demand specific reconfiguration of the DMN supports schema memory. Additionally, we found that in the control condition, which relied on episodic memory, activity in the parahippocampal gyrus was positively related to memory performance. We interpret these results as a demand specific network reconfiguration of the DMN: a decoupling of the mPFC to support schema memory and a decoupling of the parahippocampal gyrus facilitating episodic memory.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.