The association between breastmilk oligosaccharides and faecal microbiota in healthy breastfed infants at two, six, and twelve weeks of age
Publication year
2020Author(s)
Number of pages
12 p.
Source
Scientific Reports, 10, (2020), article 4270ISSN
Publication type
Article / Letter to editor

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Organization
SW OW PsKI [owi]
Cognitive Neuroscience
SW OZ BSI ON
PI Group Memory & Emotion
Journal title
Scientific Reports
Volume
vol. 10
Languages used
English (eng)
Subject
All institutes and research themes of the Radboud University Medical Center; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Social DevelopmentAbstract
Several factors affect gut microbiota development in early life, among which breastfeeding plays a key role. We followed 24 mother-infant pairs to investigate the associations between concentrations of selected human milk oligosaccharides (HMOs) in breastmilk, infant faeces, and the faecal microbiota composition in healthy, breastfed infants at two, six and 12 weeks of age. Lactation duration had a significant effect on breastmilk HMO content, which decreased with time, except for 3-fucosyllactose (3FL) and Lacto-N-fucopentaose III (LNFP III). We confirmed that microbiota composition was strongly influenced by infant age and was associated with mode of delivery and breastmilk LNFP III concentration at two weeks, with infant sex, delivery mode, and concentrations of 3'sialyllactose (3'SL) in milk at six weeks, and infant sex and Lacto-N-hexaose (LNH) in milk at 12 weeks of age. Correlations between levels of individual breastmilk HMOs and relative abundance of OTUs found in infant faeces, including the most predominant Bifidobacterium OTUs, were weak and varied with age. The faecal concentration of HMOs decreased with age and were strongly and negatively correlated with relative abundance of OTUs within genera Bifidobacterium, Parabacteroides, Escherichia-Shigella, Bacteroides, Actinomyces, Veillonella, Lachnospiraceae Incertae Sedis, and Erysipelotrichaceae Incertae Sedis, indicating the likely importance of these taxa for HMO metabolism in vivo.
This item appears in the following Collection(s)
- Academic publications [227436]
- Donders Centre for Cognitive Neuroimaging [3563]
- Electronic publications [107268]
- Faculty of Medical Sciences [86157]
- Faculty of Social Sciences [28417]
- Open Access publications [76396]
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