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      Effects of sulpiride and methylphenidate on brain and cognition: a PET pharmaco-fMRI study

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      Creators
      Määttä, J.I.M.
      Cools, R.
      Bosch, R. van den
      Hofmans, L.
      Papadopetraki, D.
      Lambregts, B.I.H.M.
      Westbrook, Andrew
      Date of Archiving
      2020
      Archive
      Radboud Data Repository
      Data archive handle
      https://hdl.handle.net/11633/aac4rtyx
      Publication type
      Dataset
      Access level
      Restricted access
      Please use this identifier to cite or link to this item: https://hdl.handle.net/2066/216589   https://hdl.handle.net/2066/216589
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      Organization
      Psychiatry
      PI Group Motivational & Cognitive Control
      Audience(s)
      Life sciences
      Languages used
      English
      Key words
      Cognitive motivation; Dopamine synthesis capacity; Decision making; Reversal learning; Striatum; pharmaco-fMRI; Reward learning; [18F]-fluoro-dopa PET; Creativity; Dopamine baseline dependency; Sulpiride; Spontaneous eye blink rate; Reward motivation; Methylphenidate; Working memory capcaity
      Abstract
      This collection is not linked to one specific publication, but contains raw data collected during the course of one project consisting of several subprojects, which will result in multiple outputs/publications. The raw data is shared here, while each subproject will be described and shared in their individual sharing collections upon publication. Design: Within-subject, double-blind, placebo-controlled, cross-over design. 100 healthy Dutch native speakers were recruited. Aim: We aim to develop a proxy-model of baseline dopamine based on machine learning methods which would provide us with behavioural predictors of the effects of dopaminergic drugs on brain and cognition that maximally generalize to new participants. Intervention: Subjects attended five study days; one screening session, three pharmaco-fMRI session (MPH, SUL and PLO) and one session for PET acquisition (carbidopa, entacapone and [18F]DOPA). Subjects completed a baseline battery measure, questionnaires, a structural MRI scan, and completed a battery of computerized tests in and outside of the fMRI scanner. Subjects received oral capsules of 20mg methylphenidate (MPH), 400mg sulpiride (SUL) and placebo (PLO) according to a double-dummy design; participants received two capsules on two separate time points per pharmaco-fMRI session. Participants received PLO or MPH 90 min after receiving PLO or SUL. For PET acquisition subjects received oral capsules of 150mg carbidopa and 400mg entacapone (about 50 min before injection), and a 185 MBq (5 mCi) [18F]-fluoro-dopa ([18F]DOPA) intravenous injection.
      This item appears in the following Collection(s)
      • Datasets [1263]
      • Donders Centre for Cognitive Neuroimaging [3391]
      • Faculty of Medical Sciences [80326]
       
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