A systematic review of the proposed mechanisms underpinning pain relief by primary motor cortex stimulation in animals
Publication year
2020Author(s)
Number of pages
11 p.
Source
Neuroscience Letters, 719, (2020), article 134489ISSN
Publication type
Article / Letter to editor
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Organization
Medical Imaging
Neurosurgery
Anesthesiology
SW OZ DCC CO
Journal title
Neuroscience Letters
Volume
vol. 719
Languages used
English (eng)
Subject
Action, intention, and motor control; All institutes and research themes of the Radboud University Medical Center; Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences; Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health Sciences; Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical NeuroscienceAbstract
Experimental treatments for treating neuropathic pain include transcranial magnetic stimulation (TMS) and invasive electric motor cortex stimulation (iMCS) of the primary motor cortex (M1). Mechanisms of action of both methods, however, remain largely elusive. Within this paper, we focus on animal-based experiments in order to investigate the biological mechanisms that are involved in alleviating pain by use of TMS and/or iMCS. Therefore, this paper systematically reviewed the animal-based evidence on these mechanisms. Multiple online databases were systematically searched and retrieved articles were assessed using predefined inclusion and exclusion criteria. Twenty-three suitable articles were included; six on TMS and seventeen on iMCS. In general, iMCS and TMS were found to impact the primary motor cortex structure and function in animals. Furthermore, structural and functional changes within the thalamus, striatum, periaqueductal grey, rostral ventromedial medulla and dorsal horn were reported to occur. Although widespread, all areas in which structural and functional changes occurred after TMS and iMCS have been found to be interconnected anatomically. This could provide a rationale for future investigations of treating neuropathic pain by use of neuromodulation.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122523]
- Faculty of Medical Sciences [90373]
- Faculty of Social Sciences [29483]
- Open Access publications [97518]
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