GABAergic changes in the thalamocortical circuit in Parkinson's disease
Number of pages
SourceHuman Brain Mapping, 41, 4, (2020), pp. 1017-1029
Article / Letter to editor
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PI Group Motivational & Cognitive Control
SW OZ DCC SMN
PI Group Systems Neurology
SW OZ DCC CO
PI Group Intention & Action
Human Brain Mapping
Subject111 000 Intention & Action; 170 000 Motivational & Cognitive Control; 240 Systems Neurology; Action, intention, and motor control; All institutes and research themes of the Radboud University Medical Center; Neuropsychology and rehabilitation psychology; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 15: Urological cancers RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience; Language in Interaction; Neuro- en revalidatiepsychologie
Parkinson's disease is characterized by bradykinesia, rigidity, and tremor. These symptoms have been related to an increased gamma‐aminobutyric acid (GABA)ergic inhibitory drive from globus pallidus onto the thalamus. However, in vivo empirical evidence for the role of GABA in Parkinson's disease is limited. Some discrepancies in the literature may be explained by the presence or absence of tremor. Specifically, recent functional magnetic resonance imaging (fMRI) findings suggest that Parkinson's tremor is associated with reduced, dopamine‐dependent thalamic inhibition. Here, we tested the hypothesis that GABA in the thalamocortical motor circuit is increased in Parkinson's disease, and we explored differences between clinical phenotypes. We included 60 Parkinson patients with dopamine‐resistant tremor (n = 17), dopamine‐responsive tremor (n = 23), or no tremor (n = 20), and healthy controls (n = 22). Using magnetic resonance spectroscopy, we measured GABA‐to‐total‐creatine ratio in motor cortex, thalamus, and a control region (visual cortex) on two separate days (ON and OFF dopaminergic medication). GABA levels were unaltered by Parkinson's disease, clinical phenotype, or medication. However, motor cortex GABA levels were inversely correlated with disease severity, particularly rigidity and tremor, both ON and OFF medication. We conclude that cortical GABA plays a beneficial rather than a detrimental role in Parkinson's disease, and that GABA depletion may contribute to increased motor symptom expression.
NWO (Grant code:info:eu-repo/grantAgreement/NWO/Gravitation/024.001.006)
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