Pedf derived peptides affect colorectal cancer cell lines resistance and tumour re-growth capacity
Publication year
2019Source
Oncotarget, 10, 31, (2019), pp. 2973-2986ISSN
Publication type
Article / Letter to editor

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Organization
Tumorimmunology
Journal title
Oncotarget
Volume
vol. 10
Issue
iss. 31
Page start
p. 2973
Page end
p. 2986
Subject
Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Relapse after chemotherapy treatment depends on the cancer initiating cells (CICs). PEDF (Pigmented Epithelium Derived Factor) is an anti-angiogenic, neurotrophic and self-renewal regulator molecule, also involved in CICs biology. Acute and chronic exposition of colon cancer cell lines to CT/CTE PEDF-derived peptides decreased drug-resistance to conventional colorectal cancer treatments, such as oxaliplatin or irinotecan. We confirmed a reduction in the irinotecan and oxaliplatin IC50 doses for all tested tumour cell lines. After xenograft transplantation, CT/CTE treatments also produced a reduction in resistance to conventional chemotherapy treatments as in culture-assays. Metastatic capacity of these treated cell lines was also depleted. The PEDF signaling pathway could be a future therapeutic tool for use as an adjuvant therapy that decreases IC50 dosis, adverse effects and treatment costs. This pathway could also be involved in an increase of the time relapse in patients, decreased tumourigenicity, and decreased capacity to produce metastasis.
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- Academic publications [227613]
- Electronic publications [107286]
- Faculty of Medical Sciences [86193]
- Open Access publications [76413]
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