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Title: How Can Systematic Reviews Teach Us More about the Implementation of the 3Rs and Animal Welfare?
Author(s): Ritskes-Hoitinga, M. ; Luijk, J. van
Publication year: 2019
Source: Animals (Basel), vol. 9, iss. 12, (2019), article E1163
ISSN: 2076-2615
DOI: https://doi.org/10.3390/ani9121163
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/215451   https://hdl.handle.net/2066/215451

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Subject: Radboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences
Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health Sciences
Organization: Health Evidence
Journal title:
Animals (Basel)
Volume: vol. 9
Issue: iss. 12
Article number: E1163
Abstract:
This paper describes the introduction of the systematic review methodology in animal-based research and the added value of this methodology in relation to the 3Rs and beyond. The 3Rs refer to Replacement, Reduction, and Refinement of animal studies. A systematic review (SR) is defined as a literature review focused on a single question that tries to identify, appraise, select, and synthesise all high-quality research evidence relevant to that question. Examples are given on how SRs lead to the implementation of the 3Rs and better science. Additionally, a broader context is given regarding societal, political, and scientific developments. Various examples of systematic reviews are given to illustrate the current situation regarding reporting, quality, and translatability of animal-based research. Furthermore, initiatives that have emerged to move further towards more responsible and sustainable research is of benefit for both animals and humans.

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