The human ventromedial prefrontal cortex: Sulcal morphology and its influence on its functional organization
Publication year
2019Number of pages
14 p.
Source
The Journal of Neuroscience, 39, 19, (2019), pp. 3627-3639ISSN
Annotation
08 mei 2019
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
SW OZ DCC SMN
Journal title
The Journal of Neuroscience
Volume
vol. 39
Issue
iss. 19
Languages used
English (eng)
Page start
p. 3627
Page end
p. 3639
Subject
Action, intention, and motor controlAbstract
The ventromedial prefrontal cortex (vmPFC), which comprises several distinct cytoarchitectonic areas, is a key brain region supporting decision-making processes, and it has been shown to be one of the main hubs of the Default Mode Network, a network classically activated during resting state. We here examined the interindividual variability in the vmPFC sulcal morphology in 57 humans (37 females) and demonstrated that the presence/absence of the inferior rostral sulcus and the subgenual intralimbic sulcus influences significantly the sulcal organization of this region. Furthermore, the sulcal organization influences the location of the vmPFC peak of the Default Mode Network, demonstrating that the location of functional activity can be affected by local sulcal patterns. These results are critical for the investigation of the function of the vmPFC and show that taking into account the sulcal variability might be essential to guide the interpretation of neuroimaging studies.
This item appears in the following Collection(s)
- Academic publications [227683]
- Electronic publications [107287]
- Faculty of Social Sciences [28418]
- Open Access publications [76415]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.