Added value of Mindfulness-Based Cognitive Therapy for Depression: A tree-based qualitative interaction analysis

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Publication year
2019Author(s)
Number of pages
12 p.
Source
Behaviour Research and Therapy, 122, (2019), article 103467ISSN
Publication type
Article / Letter to editor

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Organization
Psychiatry
SW OZ BSI KLP
Cognitive Neuroscience
PI Group MR Techniques in Brain Function
Journal title
Behaviour Research and Therapy
Volume
vol. 122
Languages used
English (eng)
Subject
150 000 MR Techniques in Brain Function; Experimental Psychopathology and Treatment; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical NeuroscienceAbstract
Aim: To identify moderators of treatment effect for Mindfulness-Based Cognitive Therapy (MBCT) versus Treatment As Usual (TAU) in depressed patients. Methods: An individual patient data-analysis was performed on three randomized-controlled trials, investigating the effect of MBCT + TAU versus TAU alone (N = 292). Patients were either in (partial) remission, currently depressed or had chronic, treatment-resistant depression. Outcomes were depressive symptoms and quality of life. The QUalitative INteraction Trees (QUINT) method was used to identify subgroups that benefited more from either condition. Results: MBCT + TAU outperformed TAU in reducing depressive symptoms. For both conditions, the effect of baseline depressive symptoms on post-treatment depressive symptoms was curvilinear. QUINT analyses revealed that MBCT + TAU was more beneficial than TAU for patients with an earlier onset and higher rumination levels in terms of depressive symptom reduction and for patients with a lower quality of life in terms of improving quality of life. Conclusions: The results suggest that MBCT might be more beneficial for those with earlier onset and higher levels of rumination and for patients with a lower quality of life. Sophisticated analytical techniques such as QUINT can be used in future research to improve personalized assignment of MBCT to patients. Long-term outcome could also be integrated in this.
This item appears in the following Collection(s)
- Academic publications [205104]
- Donders Centre for Cognitive Neuroimaging [3442]
- Electronic publications [103316]
- Faculty of Medical Sciences [81055]
- Faculty of Social Sciences [27390]
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