A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine
Publication year
2019Author(s)
Number of pages
10 p.
Source
Nature Communications, 10, (2019), article 350ISSN
Publication type
Article / Letter to editor

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Organization
Cognitive Neuroscience
Medical Imaging
Journal title
Nature Communications
Volume
vol. 10
Subject
Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical NeuroscienceAbstract
Central serotonin (5-HT) orchestrates myriad cognitive processes and lies at the core of many stress-related psychiatric illnesses. However, the basic relationship between its brain-wide axonal projections and functional dynamics is not known. Here we combine optogenetics and fMRI to produce a brain-wide 5-HT evoked functional map. We find that DRN photostimulation leads to an increase in the hemodynamic response in the DRN itself, while projection areas predominately exhibit a reduction of cerebral blood volume mirrored by suppression of cortical delta oscillations. We find that the regional distribution of post-synaptically expressed 5-HT receptors better correlates with DRN 5-HT functional connectivity than anatomical projections. Our work suggests that neuroarchitecture is not the primary determinant of function for the DRN 5-HT. With respect to two 5-HT elevating stimuli, we find that acute stress leads to circuit-wide blunting of the DRN output, while the SSRI fluoxetine noticeably enhances DRN functional connectivity. These data provide fundamental insight into the brain-wide functional dynamics of the 5-HT projection system.
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- Academic publications [227613]
- Electronic publications [107286]
- Faculty of Medical Sciences [86193]
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