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Title: Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects
Author(s): Taieb, D.; Timmers, H.J. ; Pacak, K.
Publication year: 2019
Source: Hormone and Metabolic Research, vol. 51, iss. 7, (2019), pp. 414-418
ISSN: 0018-5043
DOI: https://doi.org/10.1055/a-0586-3710
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/208793   https://hdl.handle.net/2066/208793

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Subject: Radboudumc 16: Vascular damage RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Internal Medicine
Journal title:
Hormone and Metabolic Research
Volume: vol. 51
Issue: iss. 7
Page start: p. 414
Page end: p. 418
Abstract:
The mitochondrial enzyme succinate dehydrogenase (SDH) acts as a tumor suppressor. Biallelic inactivation of one of the genes encoding for SDH subunits (collectively named SDHx) leads to complete loss of the protein function and the development of diverse group of tumors. Pheochromocytomas-paragangliomas are the prime example of hereditary tumors caused by SDH deficiency. In this review, we discuss the roles of imaging examinations, and illustrate new insights into genotype-imaging phenotype relationships.

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