Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment

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Title:	Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment
Author(s):	Geffen, E.W. van; Caam, A.P.M. van; Vitters, E.L. ; Beuningen, H.M. van ; Loo, F.A.J. van de ; Lent, P.L.E.M. van ; Koenders, M.I. ; Kraan, P.M. van der
Publication year:	2019
Source:	Tissue Engineering Part A, vol. 25, iss. 15-16, (2019), pp. 1155-1166
ISSN:	1937-3341
DOI:	https://doi.org/10.1089/ten.tea.2018.0267
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/208654
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Subject:	Radboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Rheumatology
Journal title:	Tissue Engineering Part A
Volume:	vol. 25
Issue:	iss. 15-16
Page start:	p. 1155
Page end:	p. 1166
Abstract:	IMPACT STATEMENT: Catabolic factors present in a damaged joint inhibit chondrogenic differentiation of mesenchymal stem cells, thereby reducing the chance for successful cartilage formation. By improving stem cell-based cartilage repair with interleukin-37 (IL37), we might be able to inhibit the worsening progression of focal cartilage defects and prevent further development of joint diseases such as osteoarthritis. This will avoid chronic pain and impaired joint mobility for patients and reduce costs for society.