The functional organisation of the hippocampus along its long axis is gradual and predicts recollection
SourceCortex, 119, (2019), pp. 324-335
Article / Letter to editor
Display more detailsDisplay less details
PI Group Statistical Imaging Neuroscience
Subject220 Statistical Imaging Neuroscience; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience; Language in Interaction
Understanding the functional organisation of the hippocampus is crucial for understanding its role in cognition and disorders in which it is implicated. Different views have been proposed of how function is distributed along its long axis: one view suggests segregation, whereas the alternative view postulates a more gradual organisation. Here, we applied a novel 'connectopic mapping' data-analysis approach to the resting-state fMRI data of participants of the Human Connectome Project, and demonstrate that the functional organisation of the hippocampal longitudinal axis is gradual rather than segregated into parcels. In addition, we show that inter-individual variations in this gradual organisation predict variations in recollection memory better than a characterisation based on functional parcellation. These results present an important step forward in understanding the functional organisation of the human hippocampus and have important implications for translating between rodent and human research.
NWO (Grant code:info:eu-repo/grantAgreement/NWO/Gravitation/024.001.006)
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.