The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans
Publication year
2019Source
Seminars in Nephrology, 39, 5, (2019), pp. 496-504ISSN
Publication type
Article / Letter to editor

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Organization
Intensive Care
Anesthesiology
Journal title
Seminars in Nephrology
Volume
vol. 39
Issue
iss. 5
Page start
p. 496
Page end
p. 504
Subject
Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life SciencesAbstract
The extent of the systemic inflammatory response following infectious or noninfectious insults is related to impaired patient outcome. Pregnancy is associated with immunotolerance and an increased glomerular filtration rate. EA-230 is a newly developed synthetic linear tetrapeptide derived from the "pregnancy hormone" human chorionic gonadotropin. In this review, we describe the immunomodulatory and renoprotective properties of EA-230 in preclinical animal models, phase 1 studies in humans and phase 2a studies performed during human experimental endotoxemia. In addition, details pertaining to the design of a recently completed phase 2b study in 180 patients who underwent cardiac surgery to investigate the safety and immunomodulatory and renoprotective properties of EA-230 are discussed.
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- Academic publications [227425]
- Electronic publications [107141]
- Faculty of Medical Sciences [86157]
- Open Access publications [76286]
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