The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans

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Title:	The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans
Author(s):	Groenendael, R. van; Beunders, R. ; Kox, M. ; Eijk, L.T.G.J. van ; Pickkers, P.
Publication year:	2019
Source:	Seminars in Nephrology, vol. 39, iss. 5, (2019), pp. 496-504
ISSN:	0270-9295
DOI:	https://doi.org/10.1016/j.semnephrol.2019.06.009
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/208579
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Subject:	Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Intensive Care Anesthesiology
Journal title:	Seminars in Nephrology
Volume:	vol. 39
Issue:	iss. 5
Page start:	p. 496
Page end:	p. 504
Abstract:	The extent of the systemic inflammatory response following infectious or noninfectious insults is related to impaired patient outcome. Pregnancy is associated with immunotolerance and an increased glomerular filtration rate. EA-230 is a newly developed synthetic linear tetrapeptide derived from the "pregnancy hormone" human chorionic gonadotropin. In this review, we describe the immunomodulatory and renoprotective properties of EA-230 in preclinical animal models, phase 1 studies in humans and phase 2a studies performed during human experimental endotoxemia. In addition, details pertaining to the design of a recently completed phase 2b study in 180 patients who underwent cardiac surgery to investigate the safety and immunomodulatory and renoprotective properties of EA-230 are discussed.