The role of age in treatment-related adverse events in patients with head and neck cancer: A systematic review
Publication year
2019Source
Head and Neck : Journal for the Sciences and Specialties of the Head and Neck, 41, 7, (2019), pp. 2410-2429ISSN
Publication type
Article / Letter to editor

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Organization
Otorhinolaryngology
Journal title
Head and Neck : Journal for the Sciences and Specialties of the Head and Neck
Volume
vol. 41
Issue
iss. 7
Page start
p. 2410
Page end
p. 2429
Subject
Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health SciencesAbstract
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed in advanced stage and therefore requires aggressive, multimodal treatment. Elderly patients are often excluded from standard therapy regimens purely based on age. This clinical review aims to collect all published data in the literature on treatment modality selection in elderly patients and on age-related adverse events following treatment of HNSCC. We performed a literature search for articles on the treatment of HNSCC in elderly patients. Most of the articles were retrospective studies with the consequent limitations. It can be concluded that age is not an absolute contraindication for intensive treatment and comorbidity is an important predictor of outcome, but not the only one. Despite the existence of multiple tools for pretreatment evaluation, there are not consistent data on their use.
This item appears in the following Collection(s)
- Academic publications [227881]
- Faculty of Medical Sciences [86219]
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