Targeting angiosarcomas of the soft tissues: A challenging effort in a heterogeneous and rare disease
Publication year
2019Source
Critical Reviews in Oncology Hematology, 138, (2019), pp. 120-131ISSN
Publication type
Article / Letter to editor
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Organization
Medical Oncology
Pathology
Journal title
Critical Reviews in Oncology Hematology
Volume
vol. 138
Page start
p. 120
Page end
p. 131
Subject
Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Angiosarcomas are rare malignant tumors with a heterogeneous clinical presentation and generally poor prognosis. It has been difficult to establish consistent molecular characteristics and driver events in angiosarcoma development. Oncogenic and angiogenesis-related pathways have been investigated pre-clinically and clinically with varying results. A few promising responses to checkpoint inhibitors have been described, but immunological features require further elucidation. With this review we present an overview of the critical biological pathways and processes affected in angiosarcoma, and their potential role in novel, non-cytotoxic, systemic treatments.
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- Academic publications [238441]
- Electronic publications [122508]
- Faculty of Medical Sciences [90373]
- Open Access publications [97504]
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