Eurosibs: Towards robust measurement of infant neurocognitive predictors of autism across Europe
Publication year
2019Author(s)
Number of pages
20 p.
Source
Infant Behavior and Development, 57, (2019), article 101316ISSN
Publication type
Article / Letter to editor

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Organization
SW OZ DCC CO
PI Group Memory & Emotion
Cognitive Neuroscience
Journal title
Infant Behavior and Development
Volume
vol. 57
Languages used
English (eng)
Subject
Action, intention, and motor control; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical NeuroscienceAbstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects social communication skills and flexible behaviour. Developing new treatment approaches for ASD requires early identification of the factors that influence later behavioural outcomes. One fruitful research paradigm has been the prospective study of infants with a first degree relative with ASD, who have around a 20% likelihood of developing ASD themselves. Early findings have identified a range of candidate neurocognitive markers for later ASD such as delayed attention shifting or neural responses to faces, but given the early stage of the field most sample sizes are small and replication attempts remain rare. The Eurosibs consortium is a European multisite neurocognitive study of infants with an older sibling with ASD conducted across nine sites in five European countries. In this manuscript, we describe the selection and standardization of our common neurocognitive testing protocol. We report data quality assessments across sites, showing that neurocognitive measures hold great promise for cross-site consistency in diverse populations. We discuss our approach to ensuring robust data analysis pipelines and boosting future reproducibility. Finally, we summarise challenges and opportunities for future multi-site research efforts.
This item appears in the following Collection(s)
- Academic publications [227864]
- Donders Centre for Cognitive Neuroimaging [3567]
- Electronic publications [107344]
- Faculty of Medical Sciences [86218]
- Faculty of Social Sciences [28468]
- Open Access publications [76463]
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