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      Spike and Burst Coding in Thalamocortical Relay Cells

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      Creators
      Zeldenrust, Fleur
      Chameau, Pascal
      Wadman, Wytse J.
      Date of Archiving
      2018
      Archive
      Radboud Data Repository
      Data archive handle
      https://hdl.handle.net/11633/di.dcn.DSC_626840_0002_144
      Related publications
      Spike and burst coding in thalamocortical relay cells  
      Publication type
      Dataset
      Access level
      Restricted access
      Please use this identifier to cite or link to this item: https://hdl.handle.net/2066/203810   https://hdl.handle.net/2066/203810
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      Organization
      Neurophysiology
      Audience(s)
      Life sciences
      Languages used
      English
      Key words
      burst coding; frozen white noise; information transfer; Thalamocortical Relay Neuron; bursting
      Abstract
      Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking and a bursting regime. In a combined experimental and computational study, we investigated the features in the input signal that single spikes and bursts in the output spike train represent and how this code is influenced by the membrane voltage state of the neuron. Identical frozen Gaussian noise current traces were injected into TCR neurons in rat brain slices. The information content carried by the various types of events (single spikes, bursts) in the signal as well as by the whole signal was calculated. Bursts phase-lock to and transfer information at lower frequencies than single spikes. On depolarization the neuron transits smoothly from the predominantly bursting regime to a spiking regime, in which it is more sensitive to high-frequency fluctuations.
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