Spike and Burst Coding in Thalamocortical Relay Cells
Date of Archiving2018
Radboud Data Repository
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Key wordsburst coding; frozen white noise; information transfer; Thalamocortical Relay Neuron; bursting
Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking and a bursting regime. In a combined experimental and computational study, we investigated the features in the input signal that single spikes and bursts in the output spike train represent and how this code is influenced by the membrane voltage state of the neuron. Identical frozen Gaussian noise current traces were injected into TCR neurons in rat brain slices. The information content carried by the various types of events (single spikes, bursts) in the signal as well as by the whole signal was calculated. Bursts phase-lock to and transfer information at lower frequencies than single spikes. On depolarization the neuron transits smoothly from the predominantly bursting regime to a spiking regime, in which it is more sensitive to high-frequency fluctuations.