Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex
SourceElife, 8, (2019), article e44422
Article / Letter to editor
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PI Group Predictive Brain
PI Group MR Techniques in Brain Function
SW OZ DCC CO
Subject150 000 MR Techniques in Brain Function; 180 000 Predictive Brain; Action, intention, and motor control; Biophysics
Recent developments in human neuroimaging make it possible to non-invasively measure neural activity from different cortical layers. This can potentially reveal not only which brain areas are engaged by a task, but also how. Specifically, bottom-up and top-down responses are associated with distinct laminar profiles. Here, we measured lamina-resolved fMRI responses during a visual task designed to induce concurrent bottom-up and top-down modulations via orthogonal manipulations of stimulus contrast and feature-based attention. BOLD responses were modulated by both stimulus contrast (bottom-up) and by engaging feature-based attention (top-down). Crucially, these effects operated at different cortical depths: Bottom-up modulations were strongest in the middle cortical layer and weaker in deep and superficial layers, while top-down modulations were strongest in the superficial layers. As such, we demonstrate that laminar activity profiles can discriminate between concurrent top-down and bottom-up processing, and are diagnostic of how a brain region is activated.
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