Anticipatory processes in brain state switching: Evidence from a novel cued-switching task implicating default mode and salience networks
Publication year
2014Source
NeuroImage, 98, (2014), pp. 359-365ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
PI Group Motivational & Cognitive Control
Journal title
NeuroImage
Volume
vol. 98
Page start
p. 359
Page end
p. 365
Subject
170 000 Motivational & Cognitive ControlAbstract
The default mode network (DMN) is the core brain system supporting internally oriented cognition. The ability to attenuate the DMN when switching to externally oriented processing is a prerequisite for effective performance and adaptive self-regulation. Right anterior insula (rAI), a core hub of the salience network (SN), has been proposed to control the switching from DMN to task-relevant brain networks. Little is currently known about the extent of anticipatory processes subserved by DMN and SN during switching. We investigated anticipatory DMN and SN modulation using a novel cued-switching task of between-state (rest-to-task/task-to-rest) and within-state (task-to-task) transitions. Twenty healthy adults performed the task implemented in an event-related functional magnetic resonance imaging (fMRI) design. Increases in activity were observed in the DMN regions in response to cues signalling upcoming rest. DMN attenuation was observed for rest-to-task switch cues. Obversely, DMN was up-regulated by task-to-rest cues. The strongest rAI response was observed to rest-to-task switch cues. Task-to-task switch cues elicited smaller rAI activation, whereas no significant rAI activation occurred for task-to-rest switches. Our data provide the first evidence that DMN modulation occurs rapidly and can be elicited by short duration cues signalling rest- and task-related state switches. The role of rAI appears to be limited to certain switch types — those implicating transition from a resting state and to tasks involving active cognitive engagement.
This item appears in the following Collection(s)
- Non RU Publications [15894]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.