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Title: Can Patrolling Liver-Resident T Cells Control Human Malaria Parasite Development?
Author(s): Walk, J. ; Stok, J.E.; Sauerwein, R.W.
Publication year: 2019
Source: Trends in Immunology, vol. 40, iss. 3, (2019), pp. 186-196
ISSN: 1471-4906
DOI: https://doi.org/10.1016/j.it.2019.01.002
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/202883   https://hdl.handle.net/2066/202883

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Subject: Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Medical Microbiology
Journal title:
Trends in Immunology
Volume: vol. 40
Issue: iss. 3
Page start: p. 186
Page end: p. 196
Abstract:
Recently, a population of non-recirculating, tissue-resident memory CD8(+) T cells has been identified; cells that seems to act as key sentinels for invading microorganisms with enhanced effector functions. In malaria, the liver represents the first site for parasite development before a definite infection is established in circulating red blood cells. Here, we discuss the evidence obtained from animal models on several diseases and hypothesize that liver-resident memory CD8(+) T cells (hepatic TRM) play a critical role in providing protective liver-stage immunity against Plasmodium malaria parasites. Although observations in human malaria trials are limited to peripheral blood, we propose recommendations for the translation of some of these findings to human malaria research.

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