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Publication year
2019Source
Trends in Immunology, 40, 3, (2019), pp. 186-196ISSN
Publication type
Article / Letter to editor

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Organization
Medical Microbiology
Journal title
Trends in Immunology
Volume
vol. 40
Issue
iss. 3
Page start
p. 186
Page end
p. 196
Subject
Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Recently, a population of non-recirculating, tissue-resident memory CD8(+) T cells has been identified; cells that seems to act as key sentinels for invading microorganisms with enhanced effector functions. In malaria, the liver represents the first site for parasite development before a definite infection is established in circulating red blood cells. Here, we discuss the evidence obtained from animal models on several diseases and hypothesize that liver-resident memory CD8(+) T cells (hepatic TRM) play a critical role in providing protective liver-stage immunity against Plasmodium malaria parasites. Although observations in human malaria trials are limited to peripheral blood, we propose recommendations for the translation of some of these findings to human malaria research.
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- Academic publications [227881]
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- Faculty of Medical Sciences [86219]
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