Severity, heterogeneity and systemic inflammation in psoriasis

There is no fulltext present in this item.

Title:	Severity, heterogeneity and systemic inflammation in psoriasis
Author(s):	Christophers, E.; Kerkhof, P.C.M. van de
Publication year:	2019
Source:	JEADV : Journal of the European Academy of Dermatology and Venereology, vol. 33, iss. 4, (2019), pp. 643-647
ISSN:	0926-9959
DOI:	https://doi.org/10.1111/jdv.15339
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/202854
Display more details
Subject:	Radboudumc 5: Inflammatory diseases RIHS: Radboud Institute for Health Sciences Tijdelijke code tbv inlezen publicaties Radboudumc - Alleen voor gebruik door Radboudumc
Organization:	Dermatology
Journal title:	JEADV : Journal of the European Academy of Dermatology and Venereology
Volume:	vol. 33
Issue:	iss. 4
Page start:	p. 643
Page end:	p. 647
Abstract:	Psoriasis may express as active severe disease or as mild stable disease. In particular, patients with active severe disease present systemic involvement, including comorbidities and increased values of parameters reflecting an active state of innate immunity. In contrast, patients with mild stable disease show a dominancy of acquired immunity. In this review article, we report the clinical aspects of disease manifestations of both active and quiescent psoriasis as well as the immunological aspects, as well as the impact on antimicrobial resistance. The activity of psoriasis is not captured in the present outcome measures for severity assessment. The present review suggests that incorporating disease activity may be important in the assessment of the efficacy of treatments.