The brain network in a model of thalamocortical dysrhythmia
Number of pages
SourceBrain Connectivity, 9, 3, (2019), pp. 273-284
Article / Letter to editor
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SW OZ DCC SMN
SubjectAction, intention, and motor control
Sensory information processing and higher cognitive functions rely on the interactions between thalamus and cortex. Many types of neurological and psychiatric disorders are accompanied or driven by alterations in the brain connectivity. In the present study putative changes in functional and effective cortico-cortical (CC), thalamo-cortical (TC) and cortico-thalamic (CT) connectivity during wakefulness and slow-wave sleep in a model of thalamo-cortical dysrhythmia (TCD), TRIP8b-/- mice and in control (WT) mice are described. Coherence and nonlinear Granger Causality (GC) were calculated for twenty 10 s length epochs of slow-wave sleep and active-wakefulness of each animal. Coherence was reduced between 4 and ca 20 Hz in the cortex and between cortex and thalamus during slow-wave sleep compared to active-wakefulness in WT, but not in TRIP8b-/- mice. Moreover, TRIP8b-/- mice showed lower CT coherence during active-wakefulness compared to WT mice; these differences were no longer present during slow-wave sleep. Unconditional GC analysis also showed sleep related reductions in TC and CT couplings in WT mice, while TRIP8b-/- mice showed diminished wake and enhanced sleep CC coupling and rather strong CT directed coupling during wake and sleep, albeit smaller during sleep. Conditional GC coupling analysis confirmed the diminished CC and enhanced CT coupling in TRIP8b-/- mice. Our findings indicate that altered properties of HCN channels, characterizing TRIP8b-/- mice, have clear effects on CC, TC and CT networks. A more complete understanding of the function of the altered communication within these networks awaits detailed phenotyping of TRIP8b-/- mice aimed at specifics of sensory and attentional processes.
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