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Publication year
2019Author(s)
Number of pages
5 p.
Source
European Stroke Journal, 4, 1, (2019), pp. 85-89ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Data Science
Medical Imaging
PI Group MR Techniques in Brain Function
Biophysics
Medical Psychology
SW OZ DCC NRP
Journal title
European Stroke Journal
Volume
vol. 4
Issue
iss. 1
Languages used
English (eng)
Page start
p. 85
Page end
p. 89
Subject
150 000 MR Techniques in Brain Function; All institutes and research themes of the Radboud University Medical Center; Biophysics; Data Science; Neuropsychology and rehabilitation psychology; Radboudumc 1: Alzheimer`s disease DCMN: Donders Center for Medical Neuroscience; Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience; Neuro- en revalidatiepsychologieAbstract
Introduction: Recent studies have shown that neuroimaging markers of cerebral small vessel disease can also regress over time. We investigated the cognitive consequences of regression of small vessel disease markers. Patients and methods: Two hundred and seventy-six participants of the RUNDMC study underwent neuroimaging and cognitive assessments at three time-points over 8.7 years. We semi-automatically assessed white matter hyperintensities volumes and manually rated lacunes and microbleeds. We analysed differences in cognitive decline and accompanying brain atrophy between participants with regression, progression and stable small vessel disease by analysis of variance. Results: Fifty-six participants (20.3%) showed regression of small vessel disease markers: 31 (11.2%) white matter hyperintensities regression, 10 (3.6%) vanishing lacunes and 27 (9.8%) vanishing microbleeds. Participants with regression showed a decline in overall cognition, memory, psychomotor speed and executive function similar to stable small vessel disease. Participants with small vessel disease progression showed more cognitive decline compared with stable small vessel disease (p < 0.001 for cognitive index and memory; p < 0.01 for executive function), although significance disappeared after adjusting for age and sex. Loss of total brain, gray matter and white matter volume did not differ between participants with small vessel disease regression and stable small vessel disease, while participants with small vessel disease progression showed more volume loss of total brain and gray matter compared to those with stable small vessel disease (p < 0.05), although significance disappeared after adjustments. Discussion: Regression of small vessel disease markers was associated with similar cognitive decline compared to stable small vessel disease and did not accompany brain atrophy, suggesting that small vessel disease regression follows a relatively benign clinical course. Future studies are required to validate these findings and to assess the role of vascular risk factor control on small vessel disease regression and possible recovery of clinical symptoms. Conclusion: Our findings of comparable cognitive decline between participants with regression and stable small vessel disease might suggest that small vessel disease regression has a relative benign cognitive outcome.
This item appears in the following Collection(s)
- Academic publications [227902]
- Donders Centre for Cognitive Neuroimaging [3569]
- Electronic publications [107427]
- Faculty of Medical Sciences [86234]
- Faculty of Science [33781]
- Faculty of Social Sciences [28473]
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