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Title: Trained Immunity and Local Innate Immune Memory in the Lung
Author(s): Netea, M.G. ; Joosten, L.A.B.
Publication year: 2018
Source: Cell, vol. 175, iss. 6, (2018), pp. 1463-1465
ISSN: 0092-8674
DOI: https://doi.org/10.1016/j.cell.2018.11.007
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/200485   http://hdl.handle.net/2066/200485

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Subject: Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Organization: Internal Medicine
Journal title:
Cell
Volume: vol. 175
Issue: iss. 6
Page start: p. 1463
Page end: p. 1465
Abstract:
Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNgamma release from effector CD8(+) lymphocytes initiating this process.

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