Radioactive holmium phosphate microspheres for cancer treatment
Publication year
2018Source
International Journal of Pharmaceutics, 548, 1, (2018), pp. 73-81ISSN
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Publication type
Article / Letter to editor

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Organization
Medical Imaging
Journal title
International Journal of Pharmaceutics
Volume
vol. 548
Issue
iss. 1
Page start
p. 73
Page end
p. 81
Subject
Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health SciencesAbstract
The aim of this study was the development of radioactive holmium phosphate microspheres (HoPO4-MS) with a high holmium content and that are stable in human serum for selective internal radiation therapy (SIRT) of liver cancer. To this end, holmium acetylacetonate microspheres (HoAcAc-MS) were prepared (34.2+/-1.0microm in diameter, holmium content of 46.2+/-0.8 and density of 1.7g/cm(3)) via an emulsification and solvent evaporation method. The concentration of HoAcAc in the organic solvent, the temperature of emulsification and the stirring speed were varied for the preparation of the HoAcAc-MS to obtain microspheres with different diameters ranging from 11 to 35microm. Subsequently, the AcAc ligands of the HoAcAc-MS were replaced by phosphate ions by simply incubating neutron irradiated HoAcAc-MS in a phosphate buffer solution (0.116M, pH 4.2) to yield radioactive HoPO4-MS. The obtained microspheres were analyzed using different techniques such as SEM-EDS, ICP-OES and HPLC. The prepared HoPO4-MS (29.5+/-1.2microm in diameter and a density of 3.1g/cm(3)) present an even higher holmium content (52wt%) than the HoAcAc-MS precursor (46wt%). Finally, the stability of the HoPO4-MS was tested by incubation in human serum at 37 degrees C which showed no visible changes of the microspheres morphology and only 0.1% of holmium release was observed during the 2weeks period of incubation. In conclusion, this study shows that stable radioactive HoPO4-MS can be prepared with suitable properties to be used for cancer therapy.
This item appears in the following Collection(s)
- Academic publications [227881]
- Electronic publications [107344]
- Faculty of Medical Sciences [86219]
- Open Access publications [76470]
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