Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer
Publication year
2018Source
Radiology Case Reports, 13, 6, (2018), pp. 1259-1266ISSN
Publication type
Article / Letter to editor

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Organization
Medical Oncology
Journal title
Radiology Case Reports
Volume
vol. 13
Issue
iss. 6
Page start
p. 1259
Page end
p. 1266
Subject
Radboudumc 2: Cancer development and immune defence RIHS: Radboud Institute for Health SciencesAbstract
Liver metastasis from breast cancer is associated with poor prognosis and is a major cause of early morbidity and mortality. When liver resection is not feasible, minimally invasive directed therapies are considered to attempt to prolong survival. Selective internal radiation therapy (SIRT) with yttrium-90 microspheres is a liver-directed therapy that can improve local control of liver metastases from colorectal cancer. We present a case of a patient with a ductal breast adenocarcinoma, who developed liver and bone metastasis despite extensive treatment with systemic chemotherapies. Following SIRT to the liver, after an initial response, the patient ultimately progressed in the liver after 7 months. Liver tumor histology obtained 20 months after the SIRT intervention demonstrated the presence of the resin microspheres in situ. This case report demonstrates the long-term control that may be achieved with SIRT to treat liver metastases from breast cancer that is refractory to previous chemotherapies, and the presence of microspheres in situ long-term.
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- Academic publications [227248]
- Electronic publications [108577]
- Faculty of Medical Sciences [86732]
- Open Access publications [77813]
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