Intratumoral injection of radioactive holmium ( (166) Ho) microspheres for treatment of oral squamous cell carcinoma in cats
Publication year
2018Source
Veterinary and Comparative Oncology, 16, 1, (2018), pp. 114-124ISSN
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Publication type
Article / Letter to editor

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Organization
Medical Imaging
Journal title
Veterinary and Comparative Oncology
Volume
vol. 16
Issue
iss. 1
Page start
p. 114
Page end
p. 124
Subject
Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health SciencesAbstract
BACKGROUND & AIMS: A "microbrachytherapy" was developed as treatment option for inoperable tumours by direct intratumoral injection of radioactive holmium-166 ( (166) Ho) microspheres (MS). (166) Ho emits beta-radiation which potentially enables a high, ablative, radioactive-absorbed dose on the tumour tissue while sparing surrounding tissues. MATERIALS & METHODS: Safety and efficacy of (166) Ho microbrachytherapy were evaluated in a prospective cohort study of 13 cats with inoperable oral squamous cell carcinoma without evidence of distant metastasis. RESULTS: Local response rate was 55%, including complete response or partial response (downstaging) enabling subsequent marginal resection. Median survival time was 113 days overall, and 296 days for patients with local response. Side effects were minimal. Tumour volume was a significant predictor of response. DISCUSSION: Response rate may be further improved by optimizing the intratumoral spatial distribution of (166) Ho MS. CONCLUSION: (166) Ho microbrachytherapy has potential as a minimally invasive, single procedure radio-ablation treatment of unresectable tumours with minimal morbidity.
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- Academic publications [227425]
- Electronic publications [107141]
- Faculty of Medical Sciences [86157]
- Open Access publications [76287]
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