Firing Up Glycolysis: BCG Vaccination Effects on Type 1 Diabetes Mellitus
until further notice
SourceTrends in Endocrinology and Metabolism, 29, 12, (2018), pp. 813-814
Article / Letter to editor
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Trends in Endocrinology and Metabolism
SubjectRadboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 6: Metabolic Disorders RIMLS: Radboud Institute for Molecular Life Sciences
In addition to the impact of Bacillus Calmette-Guerin (BCG) vaccination on antimicrobial host defence, a novel study reveals beneficial effects on glycaemic control in patients with long-standing type 1 diabetes mellitus (T1DM). These effects are ascribed to an accelerated glucose consumption in immune cells due to increased glycolysis and reduced oxidative phosphorylation.
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