MRI-Guided Biopsy as a Tool for Diagnosis and Research of Muscle Disorders

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Title:	MRI-Guided Biopsy as a Tool for Diagnosis and Research of Muscle Disorders
Author(s):	Lassche, S. ; Janssen, B.H.; Ijzermans, T.; Futterer, J.J. ; Voermans, N.C. ; Heerschap, A. ; Kusters, B. ; Mann, R.M. ; Engelen, B.G.M. van
Publication year:	2018
Source:	Journal of Neuromuscular Diseases, vol. 5, iss. 3, (2018), pp. 315-319
ISSN:	2214-3599
DOI:	https://doi.org/10.3233/JND-180318
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/196635
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Subject:	Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences Radboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences Radboudumc 15: Urological cancers RIMLS: Radboud Institute for Molecular Life Sciences Radboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience
Organization:	Neurology Radiology & Nuclear Medicine Radboudumc Extern Pathology
Journal title:	Journal of Neuromuscular Diseases
Volume:	vol. 5
Issue:	iss. 3
Page start:	p. 315
Page end:	p. 319
Abstract:	BACKGROUND: Sampling error is a common problem in muscle biopsies. MRI-guided biopsy allows verification of biopsy site during the procedure, which may reduce sampling error in patients with focal disease. OBJECTIVES: To describe the technique for MRI-guided muscle biopsy and discuss potential applications. METHODS: Axial MRI images were acquired to determine the target site for muscle biopsy. Needle trajectory was planned on 3D T1 weighted imaging and a MRI-guided biopsy of the vastus lateralis was performed in 13 FSHD patients. RESULTS: An adequate amount of muscle tissue was obtained in all participants, and MRI-guided biopsy succeeded in reaching focal target sites. However, symptomatic hematomas were observed in 2/13 patientsDiscussion:MRI-guided biopsy has a higher complication rate compared to traditional needle biopsy, most likely due to proximity to blood vessels in combination with the vacuum-assisted suction of the MRI-guided technique. We recommend that this technique is reserved for select diagnostic cases and research questions, with careful assessment of vasculature and reduced suction levels.