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Publication year
2018Source
Current Opinion in Neurology, 31, 5, (2018), pp. 568-574ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Orthopaedics
Medical Imaging
Journal title
Current Opinion in Neurology
Volume
vol. 31
Issue
iss. 5
Page start
p. 568
Page end
p. 574
Subject
Radboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences; Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical NeuroscienceAbstract
PURPOSE OF REVIEW: This review focuses on developments in muscle ultrasound as a noninvasive and accurate tool for the diagnosis and follow-up of neuromuscular disease. It discusses current muscle ultrasound applications with already proven clinical value, and highlights recent technical developments that may further advance muscle ultrasounds' diagnostic qualities. RECENT FINDINGS: The sensitivity and specificity of muscle ultrasound for detecting a neuromuscular disorder are high (90-95%), and quantitative ultrasound is well suited to monitor disease progression in several disorders. Adding ultrasound to electromyography significantly improves diagnostic certainty in patients with suspected motor neuron disease, and ultrasound increases the detection of fasciculations with 30-50%. New developments include speckle tracking of tissue motion to quantify diaphragm excursions and diminished muscle contractility in dystrophy, and strain elastography to detect changes in muscle stiffness and anisotropy during contraction and in disease states. Deep learning algorithms are being developed to predict the presence of a muscle disease and differentiate between disorders. SUMMARY: Muscle ultrasound is excellent for screening, diagnosing, and follow-up of neuromuscular disease. New developments are underway to automate and objectify the diagnostic process, and to quantify tissue motion that can provide new insights in pathophysiology and serve as a biomarker.
This item appears in the following Collection(s)
- Academic publications [227425]
- Electronic publications [107155]
- Faculty of Medical Sciences [86157]
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