T Cell Metabolism Has Evolved to Tolerate Tuberculosis
until further notice
SourceCell Metabolism, 28, 3, (2018), pp. 332-333
Article / Letter to editor
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SubjectRadboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Although T cells are important in preventing tuberculosis progression, their role in disease tolerance is unknown. Recently in Science Immunology, Tzelepis et al. (2018) have revealed that mitochondrial cyclophilin D controls T cell metabolism and proliferation, contributing to tolerance. Cyclophilin D loss leads to immunopathology and increased mortality, without impacting bacterial burden.
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