Clinical pharmacology of antiretroviral agents: Focus on drug interactions and dose optimization.
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RU Radboud Universiteit Nijmegen, 14 april 2005
Promotor : Hekster, Y.A. Co-promotores : Burger, D.M., Koopmans †, P.P.
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SubjectUMCN 4.1: Microbial pathogenesis and host defense
This thesis comprises research with a number of licensed antiretroviral agents. The subject of research was the occurrence of (un)wanted drug interactions and possibilities for dose optimization. Studies were performed with the difficult combination of antiretroviral agents and tuberculostatic drugs, interactions with food and the effect of different adjusted dosages. It was found that dose adjustments make it possible to combine the antiretroviral protease inhibitor lopinavir with the tuberculostatic drug rifampin. Furthermore other studies showed that dose adjustments in case of subtherapeutic plasma drug concentrations were not always successful. In the group of non-nucleoside reverse transcriptase inhibitors it was seen that non-caucasian patients and female patients were at risk for higher plasma drug levels, with possibly more toxicity as a result
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