Can Gentamicin-collagen Sponges Prevent Seroma Formation Following Mastectomy?

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Title:	Can Gentamicin-collagen Sponges Prevent Seroma Formation Following Mastectomy?
Author(s):	Wolde, B. Ten; Wildenberg, F.J. van den; Polat, F.; Wilt, J.H.W. de ; Strobbe, L.J.A.
Publication year:	2018
Source:	Clinical Breast Cancer, vol. 18, iss. 5, (2018), pp. e1023-e1026
ISSN:	1526-8209
DOI:	https://doi.org/10.1016/j.clbc.2018.02.011
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/195724
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Subject:	Radboudumc 14: Tumours of the digestive tract RIHS: Radboud Institute for Health Sciences
Organization:	Surgery
Journal title:	Clinical Breast Cancer
Volume:	vol. 18
Issue:	iss. 5
Page start:	p. e1023
Page end:	p. e1026
Abstract:	BACKGROUND: The aim of this study was to investigate whether gentamicin-collagen (GC) sponges can lower the incidence of seroma and surgical site infections following breast cancer surgery. PATIENTS AND METHODS: A retrospective cohort study was performed. Two consecutive cohorts of patients who underwent a mastectomy with or without an axillary lymph node dissection were compared. The first cohort was treated conventionally (n = 38), the second cohort received GC sponges (n = 39). Endpoints were the incidence of clinical significant seroma (CSS) and surgical site infections (SSI), the mean number of aspirations, and the mean aspirated volume. RESULTS: GC sponges lowered the CSS incidence from 73.7% to 38.5% (P = .002). The mean number of aspirations and the mean aspirated volume were not affected. SSI incidence was 15.8% in the conventional cohort compared with 7.7% in the GC cohort (P = .23). CONCLUSION: Application of GC sponges significantly lowered the incidence of CSS. The incidence of SSI was halved, although this was not significant.