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Publication year
2018Source
Trends in Immunology, 39, 5, (2018), pp. 380-392ISSN
Publication type
Article / Letter to editor
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Organization
Radiation Oncology
Anesthesiology
Journal title
Trends in Immunology
Volume
vol. 39
Issue
iss. 5
Page start
p. 380
Page end
p. 392
Subject
Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences; Anesthesiology - Radboud University Medical Center; Radiation Oncology - Radboud University Medical CenterAbstract
Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are increasingly recognized as dynamic players in lipid metabolism, with important roles not only in diseases such as diabetes and cancer, but also in immune regulation. Alterations in immune cell function, such as myeloid cell activation, are connected to profound changes in LD numbers and LD protein composition. Thus, these organelles appear to be essential to metabolically support immune responses, and have a vital role in antigen crosspresentation, interferon (IFN) responses, production of inflammatory mediators, and pathogen clearance. Here, we review recent studies that report on the role of LDs in the modulation of immune cell function, primarily focusing on myeloid cells, such as macrophages and dendritic cells (DCs).
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- Electronic publications [134241]
- Faculty of Medical Sciences [93461]
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