Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint

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Title:	Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint
Author(s):	Kraan, P.M. van der
Publication year:	2018
Source:	Journal of Bone Metabolism, vol. 25, iss. 2, (2018), pp. 65-72
ISSN:	2287-6375
DOI:	https://doi.org/10.11005/jbm.2018.25.2.65
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/193603
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Subject:	Radboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Rheumatology
Journal title:	Journal of Bone Metabolism
Volume:	vol. 25
Issue:	iss. 2
Page start:	p. 65
Page end:	p. 72
Abstract:	Transforming growth factor-beta (TGF-beta) is a cytokine that plays an important role in both normal joints and joints affected by osteoarthritis (OA), the most common joint disease. However, the role of this pleiotropic cytokine in a normal healthy joint is very different from its role in an OA joint. In a normal synovial joint, active TGF-beta is only present after joint loading and only for a short period. In contrast, permanent and high levels of active TGF-beta are detected in OA joints. Due to this difference in levels and exposure period of joint cells to active TGF-beta, the function of TGF-beta is strikingly different in normal and OA joints. The consequences of this difference in TGF-beta levels on joint homeostasis and pathological changes in OA joints are discussed in this review.