Title: | Metrics to assess the quantity of antibiotic use in the outpatient setting: a systematic review followed by an international multidisciplinary consensus procedure |
Author(s): | Versporten, A.; Gyssens, I.C.J. ; Pulcini, C.; Monnier, A.A. ; Schouten, J.A. ; Milanic, R.; Benic, M. Stanic; Tebano, G.; Marechal, M. Le; Zanichelli, V.; Huttner, B.; Vlahovic-Palcevski, V.; Goossens, H.; Wertheim, H.F.L. ; Hulscher, M.E. ; Adriaenssens, N. |
Publication year: | 2018 |
Source: | Journal of Antimicrobial Chemotherapy, vol. 73, iss. suppl_6, (2018), pp. vi59-vi66 |
ISSN: | 0305-7453 |
DOI: | https://doi.org/10.1093/jac/dky119 |
Publication type: | Article / Letter to editor |
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/193592 ![]() |
|
Subject: | Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences Tijdelijke code tbv inlezen publicaties Radboudumc - Alleen voor gebruik door Radboudumc |
Organization: | Internal Medicine Intensive Care Medical Microbiology Primary and Community Care IQ Healthcare |
Journal title: |
Journal of Antimicrobial Chemotherapy
|
Volume: | vol. 73 |
Issue: | iss. suppl_6 |
Page start: | p. vi59 |
Page end: | p. vi66 |
Abstract: |
Background: The international Innovative Medicines Initiative (IMI) project DRIVE-AB (Driving Reinvestment in Research and Development and Responsible Antibiotic Use) aims to develop a global definition of 'responsible' antibiotic use. Objectives: To identify consensually validated quantity metrics for antibiotic use in the outpatient setting. Methods: First, outpatient quantity metrics (OQMs) were identified by a systematic search of literature and web sites published until 12 December 2014. Identified OQMs were evaluated by a multidisciplinary, international stakeholder panel using a RAND-modified Delphi procedure. Two online questionnaires and a face-to-face meeting between them were conducted to assess OQM relevance for measuring the quantity of antibiotic use on a nine-point Likert scale, to add comments or to propose new metrics. Results: A total of 597 articles were screened, 177 studies met criteria for full-text screening and 138 were finally included. Twenty different OQMs were identified and appraised by 23 stakeholders. During the first survey, 14 OQMs were excluded and 6 qualified for discussion. During the face-to-face meeting, 10 stakeholders retained five OQMs and suggestions were made considering context and combination of metrics. The final set of metrics included defined daily doses, treatments/courses and prescriptions per defined population, treatments/courses and prescriptions per defined number of physician contacts and seasonal variation of total antibiotic use. Conclusions: A small set of consensually validated metrics to assess the quantity of antibiotic use in the outpatient setting was obtained, enabling (inter)national comparisons. The OQMs will help build a global conceptual framework for responsible antibiotic use.
|