Periodontal regeneration via chemoattractive constructs.
SourceJournal of Clinical Periodontology, 45, 7, (2018), pp. 851-860
1 juli 2018
Article / Letter to editor
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Journal of Clinical Periodontology
SubjectRadboudumc 0: Other Research RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 10: Reconstructive and regenerative medicine RIMLS: Radboud Institute for Molecular Life Sciences
AIM: Chemoattractants, such as stromal cell-derived factor-1alpha (SDF-1alpha), can offer an advantage for periodontal regeneration by recruiting the patient's own stem cells to stimulate self-repair. We here developed a chemoattractive construct for periodontal regeneration using SDF-1alpha and evaluated its efficacy in vivo. MATERIALS AND METHODS: SDF-1alpha was loaded on gelatin sponge and tested in vitro for SDF-1alpha release. Subsequently, SDF-1alpha constructs were implanted into rat periodontal defects for 1 and 6 weeks, with unloaded materials and empty defects as controls. The regenerative efficacy was evaluated by micro-CT, histological and histomorphometrical analyses. RESULTS: In vitro results showed limited SDF-1alpha release up to 35 days. In contrast, SDF-1alpha constructs significantly improved periodontal defect regeneration in terms of alveolar bone height, new bone area and functional ligament length. Additionally, SDF-1alpha constructs decreased the inflammatory response at Week 6. CONCLUSION: Chemoattractive constructs significantly improved periodontal regeneration in terms of alveolar bone height, new bone area and functional ligament length.
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