Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

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Title:	Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations
Author(s):	Rebbeck, T.R.; Friebel, T.M.; Friedman, E.; Hamann, U.; Huo, D.; Kwong, A.; Olah, E.; Olopade, O.I.; Solano, A.R.; Teo, S.H.; Thomassen, M.; Weitzel, J.N.; Chan, T.L.; Couch, F.J.; Goldgar, D.E.; Kruse, T.A.; Palmero, E.I.; Park, S.K.; Torres, D.; Rensburg, E.J. van; McGuffog, L.; Parsons, M.T.; Leslie, G.; Aalfs, C.M.; Abugattas, J.; Adlard, J.; Agata, S.; Aittomaki, K.; Andrews, L.; Andrulis, I.L.; Arason, A.; Arnold, N.; Arun, B.K.; Asseryanis, E.; Auerbach, L.; Azzollini, J.; Balmana, J.; Barile, M.; Barkardottir, R.B.; Barrowdale, D.; Benitez, J.; Berger, A.; Berger, R.; Blanco, A.M.; Blazer, K.R.; Blok, M.J.; Bonadona, V.; Bonanni, B.; Bradbury, A.R.; Brewer, C.; Buecher, B.; Buys, S.S.; Caldes, T.; Caliebe, A.; Caligo, M.A.; Campbell, I.; Caputo, S.M.; Chiquette, J.; Chung, W.K.; Claes, K.B.M.; Collee, J.M.; Cook, J. ; Davidson, R.; Hoya, M. de la; Leeneer, K. De; Pauw, A. de; Delnatte, C.; Diez, O.; Ding, Y.C.; Ditsch, N.; Domchek, S.M.; Dorfling, C.M.; Velazquez, C.; Dworniczak, B.; Eason, J.; Easton, D.F.; Eeles, R.; Ehrencrona, H.; Ejlertsen, B.; Engel, C.; Engert, S.; Evans, D.G.; Faivre, L.; Feliubadalo, L.; Ferrer, S.F.; Foretova, L.; Fowler, J.; Frost, D.; Galvao, H.C.R.; Ganz, P.A.; Garber, J.; Gauthier-Villars, M.; Gehrig, A.; Gerdes, A.M.; Gesta, P.; Giannini, G.; Giraud, S.; Glendon, G.; Godwin, A.K.; Greene, M.H.; Mensenkamp, A.R. ; Antoniou, A.C.; Nathanson, K.L.
Publication year:	2018
Source:	Human Mutation, vol. 39, iss. 5, (2018), pp. 593-620
Number of Pages:	28 p.
ISSN:	1059-7794
DOI:	https://doi.org/10.1002/humu.23406
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/193394
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Subject:	Radboudumc 14: Tumours of the digestive tract RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Radboudumc Extern Human Genetics
Journal title:	Human Mutation
Volume:	vol. 39
Issue:	iss. 5
Page start:	p. 593
Page end:	p. 620
Abstract:	The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on White in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutations ascertained from 69 centers in 49 countries on six continents. This study comprehensively describes the characteristics of the 1,650 unique BRCA1 and 1,731 unique BRCA2 deleterious (disease-associated) mutations identified in the CIMBA database. We observed substantial variation in mutation type and frequency by geographical region and race/ethnicity. In addition to known founder mutations, mutations of relatively high frequency were identified in specific racial/ethnic or geographic groups that may reflect founder mutations and which could be used in targeted (panel) first pass genotyping for specific populations. Knowledge of the population-specific mutational spectrum in BRCA1 and BRCA2 could inform efficient strategies for genetic testing and may justify a more broad-based oncogenetic testing in some populations.
Languages used:	English (eng)